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Stirred Tank Bioreactors

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Stirred Tank Bioreactors

BRS bioreactor product line offers the benefits of singleuse technology and stirredtank design in a modular, turnkey, bioreactor platform. Designed for scalability and robustness, theBRS bioreactor systems provide the performance and flexibility needed from process development to largescale biopharmaceutical manufacturing. BRS single-use bioreactor systems can be operated in batch, fedbatch, and perfusion modes.

BRS single-use stirred bioreactor composed of a stainless steel container, a single-use cell cultre bag abf a controller equipped with excellent sensors.

BRS bioreactor can match the bags volume from 50L to 2000L, and is easy achieve suspension cell culture and micro-carrier/fabric carrier adherent cell culture.

Features

Sterility/enclosed/low cost. Enclosed environment with low contamination risks and less maintenance.

Convenient validation and operation. No need for cleaning and sterility validation with low contamination risks.

Customization. Modular design enables configurability and provides added flexibility.

Scale-up. Predictable and seam less process scalability. 50L to 2000L available.

Monitoring. Monitoring cell culture process.

Application

Culture of mammalian cells/insect/stem cell

Adherent cell culture on micro-carriers or fabric carriers

Manufacturing of vaccines, recombinant proteins and antibodies

Medium and low density microbal cell culture

Large-scale seed culture

Specification

Total volume

50L

200L

500L

1000L

2000L

Max.spedd

360 rpm

350 rpm

250 rpm

140 rpm

115 rpm

Control system

Siemens PLC, 15-inch color touch screen, Enthernet interface, USB interface

Temperature control

Water jacket, PID automatic control, Pt1—sensor, accuracy: ±0.5˚C; PID control, temperature range: 8-45˚C, Max. 60˚C

Gas

4 Thermal mass flow controllers (Air/O2/N2/CO2), a thermal mass flow controller with 3 gas mixer and overlay optional

Exhaust

Filter heater/ 0.2µm air filter

Exhaust analysis

O2 (0-50%), CO2 (0-15%)

Gas pressure control

Measured and controlled

1. Single-use fiber pH probe, control range: 6-8, accuracy: ±0.05 pH; PID control; cascaded by CO2 concentration, peristaltic pump, etc.

2. Repeatable use of traditional pH probe with sterilizable electrode adapter, control range: 4-10; PID control; cascaded by CO2 concentration, peristaltic pump, etc.

1.Single-use DO probe, control range: 0-100%; PID control; cascaded by rocker speed, MFC, etc.

2.Repeatable use of traditional DO probe with sterilizable electrode adapter, control range: 0-100%; PID control; cascaded by rocker speed, MFC, etc.

Pumps

4 fixed-speed peristaltic pumps for addition/ acid / alkali / anti-foam etc. 25 RPM or 100RPM variable speed optional

Load cell

Optional

Utilities

Air / O2 / CO2, pressure 15-20 PSIG

Signal interface

Optional

Power supply

AC220V, 50/60 Hz, 10A